Subject and purpose of work: The aim of this paper is to make an analysis and evaluation of Lyme disease incidence, understood as a diagnosed farmers’ occupational disease. Materials and methods: The analysis and an evaluation were made based on materials, data and information originating, among other things, from the following: The analysis and an evaluation were made based on materials, data and information originating, among other things, from the following: The Agricultural Social Insurance Fund, the Main Sanitary Inspectorate and the National Institute of Hygiene, official legal acts published in the Journal of Laws, industry literature, as well as works and publications of researchers dealing with Lyme disease. Results: The results of this study indicate that Lyme disease is not only the main and dominant occupational disease of farmers, but also an infectious disease having a growing trend among Polish society. Every year, an increase in cases in which Lyme disease spirochete infection was found and diagnosed, is observed. This situation is affected not only by insufficient preventive measures, difficult and ineffective diagnostics, or low awareness of Lyme disease, but also by environmental factors and climate change. Conclusions: C onsidering that the disease leads to numerous dangerous health-related consequences, while a protective vaccine has not yet been prepared, it seems extremely important to implement preventive measures and conduct education on prevention among farmers as well as other professional groups and the entire population.