Subject and purpose of work: The subject of work are the Euro regions as institutions of crossborder cooperation organized at the borders of member states of the European Union and border regions of the neighbouring countries. The objective of the work is to present the functioning in Europe of models of trans-border cooperation development as well as an assessment of various forms of Euro regions created at the borderland of Ukraine. Materials and methods: The author used official statistical data as well as legal regulations in place and information regarding activity of euro regions and subject literature. Results and conclusions: Within the work organizational infrastructure and the functioning of euro regions at the border of Ukraine were described in the short, medium and long perspective. Further development of trans-border cooperation requires strengthening of institutional structure of euro regions and a larger engagement of economic entties and social organs in cross-border areas.