Subject and purpose of work: In the contemporary global economy, regional trade agreements (RTAs) and economic multilateral frameworks are crucial for establishing comprehensive norms and standards that enhance international trade, including the protection of intellectual property rights (IPR). This paper examines the role of IPR coherence in fostering trade and innovation, focusing on the European Union (EU) and the Regional Comprehensive Economic Partnership (RCEP). Materials and methods: Through a comparative analysis, the paper provides insights into the complex dynamics between developed and developing regions, emphasizing the importance of harmonized IPR standards for a more inclusive and integrated global market. Results: The EU, with its stringent regulatory standards, contrasts with the more flexible IPR approaches of the diverse Asia-Pacific nations in RCEP. The study explores the necessity and benefits of harmonizing these IPR frameworks to improve trade relations and stimulate innovation. It highlights China’s pragmatic strategy in aligning its evolving IP regulations with international standards while accommodating the needs of ASEAN countries. Conclusions: The findings suggest pathways for enhancing IP protection standards and fostering mutual economic growth and innovation.